DRD1

dopamine receptor D1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
temperature homeostasis [GO:0001659],
conditioned taste aversion [GO:0001661],
behavioral fear response [GO:0001662],
regulation of protein phosphorylation [GO:0001932],
synaptic transmission, dopaminergic [GO:0001963],
response to amphetamine [GO:0001975],
protein import into nucleus [GO:0006606],
G-protein coupled receptor signaling pathway [GO:0007186],
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187],
adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
activation of adenylate cyclase activity [GO:0007190],
adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191],
dopamine receptor signaling pathway [GO:0007212],
synapse assembly [GO:0007416],
memory [GO:0007613],
mating behavior [GO:0007617],
grooming behavior [GO:0007625],
adult walking behavior [GO:0007628],
visual learning [GO:0008542],
positive regulation of gene expression [GO:0010628],
astrocyte development [GO:0014002],
dopamine transport [GO:0015872],
transmission of nerve impulse [GO:0019226],
neuronal action potential [GO:0019228],
dentate gyrus development [GO:0021542],
striatum development [GO:0021756],
cerebral cortex GABAergic interneuron migration [GO:0021853],
positive regulation of cell migration [GO:0030335],
peristalsis [GO:0030432],
operant conditioning [GO:0035106],
regulation of dopamine metabolic process [GO:0042053],
vasodilation [GO:0042311],
dopamine metabolic process [GO:0042417],
response to drug [GO:0042493],
maternal behavior [GO:0042711],
positive regulation of potassium ion transport [GO:0043268],
histone H3-S10 phosphorylation [GO:0043987],
glucose import [GO:0046323],
habituation [GO:0046959],
sensitization [GO:0046960],
behavioral response to cocaine [GO:0048148],
positive regulation of release of sequestered calcium ion into cytosol [GO:0051281],
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482],
regulation of dopamine uptake involved in synaptic transmission [GO:0051584],
positive regulation of synaptic transmission, glutamatergic [GO:0051968],
prepulse inhibition [GO:0060134],
phospholipase C-activating dopamine receptor signaling pathway [GO:0060158],
long-term synaptic potentiation [GO:0060291],
long term synaptic depression [GO:0060292],
cellular response to catecholamine stimulus [GO:0071870],
adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880],
cellular response to dopamine [GO:1903351],
regulation of synaptic vesicle exocytosis [GO:2000300],
positive regulation of protein phosphorylation [GO:0001934],
startle response [GO:0001964],
negative regulation of protein kinase activity [GO:0006469],
intracellular protein transport [GO:0006886],
muscle contraction [GO:0006936],
signal transduction [GO:0007165],
learning [GO:0007612],
locomotory behavior [GO:0007626],
feeding behavior [GO:0007631],
associative learning [GO:0008306],
regulation of vasoconstriction [GO:0019229],
calcium-mediated signaling [GO:0019722],
hippocampus development [GO:0021766],
negative regulation of cell migration [GO:0030336],
social behavior [GO:0035176],
response to cocaine [GO:0042220],
negative regulation of circadian sleep/wake cycle, sleep [GO:0042321],
eating behavior [GO:0042755],
regulation of ion transport [GO:0043269],
positive regulation of membrane potential [GO:0045838],
regulation of long-term neuronal synaptic plasticity [GO:0048169],
negative regulation of cell death [GO:0060548],
modification of postsynaptic structure [GO:0099010],
positive regulation of long-term synaptic potentiation [GO:1900273],
positive regulation of feeding behavior [GO:2000253],

Molecular Function:
dopamine neurotransmitter receptor activity, coupled via Gs [GO:0001588],
G-protein coupled receptor activity [GO:0004930],
dopamine neurotransmitter receptor activity [GO:0004952],
protein binding [GO:0005515],
dopamine binding [GO:0035240],
G-protein alpha-subunit binding [GO:0001965],
receptor binding [GO:0005102],
drug binding [GO:0008144],
protein phosphatase binding [GO:0019903],
angiotensin receptor binding [GO:0031701],
D3 dopamine receptor binding [GO:0031750],
macromolecular complex binding [GO:0044877],
ATPase binding [GO:0051117],

Cellular Component:
nucleus [GO:0005634],
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cilium [GO:0005929],
dendritic spine [GO:0043197],
ciliary membrane [GO:0060170],
non-motile cilium [GO:0097730],
9+0 non-motile cilium [GO:0097731],
glutamatergic synapse [GO:0098978],
GABA-ergic synapse [GO:0098982],
integral component of postsynaptic membrane [GO:0099055],
integral component of presynaptic membrane [GO:0099056],
endoplasmic reticulum [GO:0005783],
caveola [GO:0005901],
endomembrane system [GO:0012505],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
axon [GO:0030424],
dendrite [GO:0030425],
cell projection [GO:0042995],
neuronal cell body [GO:0043025],
dendritic shaft [GO:0043198],
axon terminus [GO:0043679],
dendritic spine neck [GO:0044326],
dendritic spine head [GO:0044327],
synapse [GO:0045202],