dihydropyrimidine dehydrogenase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945054 IMR-90 Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
purine nucleobase catabolic process [GO:0006145],
pyrimidine nucleobase catabolic process [GO:0006208],
thymine catabolic process [GO:0006210],
uracil catabolic process [GO:0006212],
thymidine catabolic process [GO:0006214],
beta-alanine biosynthetic process [GO:0019483],
pyrimidine nucleoside catabolic process [GO:0046135],
oxidation-reduction process [GO:0055114],
response to nutrient [GO:0007584],
circadian rhythm [GO:0007623],
response to organic cyclic compound [GO:0014070],
uracil metabolic process [GO:0019860],
response to drug [GO:0042493],

Molecular Function:
uracil binding [GO:0002058],
protein binding [GO:0005515],
dihydropyrimidine dehydrogenase (NADP+) activity [GO:0017113],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
flavin adenine dinucleotide binding [GO:0050660],
NADP binding [GO:0050661],
iron-sulfur cluster binding [GO:0051536],
4 iron, 4 sulfur cluster binding [GO:0051539],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
dihydrouracil dehydrogenase (NAD+) activity [GO:0004159],
iron ion binding [GO:0005506],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627],
identical protein binding [GO:0042802],
FAD binding [GO:0071949],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],