A-kinase anchoring protein 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
protein targeting [GO:0006605],
signal transduction [GO:0007165],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
negative regulation of adenylate cyclase activity [GO:0007194],
chemical synaptic transmission [GO:0007268],
regulation of protein kinase A signaling [GO:0010738],
positive regulation of adenylate cyclase activity [GO:0045762],
positive regulation of long-term synaptic potentiation [GO:1900273],
positive regulation of protein localization to plasma membrane [GO:1903078],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of calcium ion transport into cytosol [GO:0010524],
amylase secretion [GO:0036394],
positive regulation of protein import into nucleus [GO:0042307],
receptor clustering [GO:0043113],
negative regulation of potassium ion transport [GO:0043267],
negative regulation of ion transport [GO:0043271],
cellular protein complex disassembly [GO:0043624],
clustering of voltage-gated potassium channels [GO:0045163],
positive regulation of dendrite morphogenesis [GO:0050775],
clustering of voltage-gated calcium channels [GO:0070073],
positive regulation of calcineurin-NFAT signaling cascade [GO:0070886],

Molecular Function:
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
adenylate cyclase binding [GO:0008179],
SH3 domain binding [GO:0017124],
protein phosphatase 2B binding [GO:0030346],
beta-2 adrenergic receptor binding [GO:0031698],
protein kinase A regulatory subunit binding [GO:0034237],
glutamate receptor binding [GO:0035254],
GABA receptor binding [GO:0050811],
protein kinase A binding [GO:0051018],
binding, bridging [GO:0060090],
scaffold protein binding [GO:0097110],
G-protein coupled receptor binding [GO:0001664],
actin binding [GO:0003779],
kinase binding [GO:0019900],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
macromolecular complex binding [GO:0044877],
cadherin binding [GO:0045296],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cytoplasmic side of plasma membrane [GO:0009898],
postsynaptic density [GO:0014069],
dendrite membrane [GO:0032590],
dendritic spine [GO:0043197],
membrane raft [GO:0045121],
excitatory synapse [GO:0060076],
postsynaptic recycling endosome [GO:0098837],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
dendrite [GO:0030425],
filopodium membrane [GO:0031527],
asymmetric synapse [GO:0032279],
dendritic spine membrane [GO:0032591],
macromolecular complex [GO:0032991],
neuronal cell body [GO:0043025],
dendritic shaft [GO:0043198],
perinuclear region of cytoplasm [GO:0048471],
glutamatergic synapse [GO:0098978],