A-kinase anchoring protein 13

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
protein phosphorylation [GO:0006468],
G-protein coupled receptor signaling pathway [GO:0007186],
heart development [GO:0007507],
regulation of Rho protein signal transduction [GO:0035023],
positive regulation of Rho protein signal transduction [GO:0035025],
positive regulation of apoptotic process [GO:0043065],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of MAP kinase activity [GO:0043406],
regulation of small GTPase mediated signal transduction [GO:0051056],
nuclear export [GO:0051168],
cardiac muscle cell differentiation [GO:0055007],
regulation of sarcomere organization [GO:0060297],
bone development [GO:0060348],
cell growth involved in cardiac muscle cell development [GO:0061049],
adrenergic receptor signaling pathway [GO:0071875],
adrenergic receptor signaling pathway involved in heart process [GO:0086023],
regulation of glucocorticoid mediated signaling pathway [GO:1900169],
intracellular signal transduction [GO:0035556],

Molecular Function:
cAMP-dependent protein kinase activity [GO:0004691],
MAP-kinase scaffold activity [GO:0005078],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
protein binding [GO:0005515],
Rho GTPase binding [GO:0017048],
metal ion binding [GO:0046872],
protein kinase A binding [GO:0051018],
binding, bridging [GO:0060090],
guanyl-nucleotide exchange factor activity [GO:0005085],

Cellular Component:
nucleus [GO:0005634],
cytosol [GO:0005829],
actin filament [GO:0005884],
cell cortex [GO:0005938],
actin cytoskeleton [GO:0015629],
membrane [GO:0016020],
cortical actin cytoskeleton [GO:0030864],
perinuclear region of cytoplasm [GO:0048471],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],