DOCK4
dedicator of cytokinesis 4
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
GO terms:
Biological Process:
small GTPase mediated signal transduction [GO:0007264],
positive regulation of GTPase activity [GO:0043547],
cell chemotaxis [GO:0060326],
negative regulation of vascular smooth muscle contraction [GO:1904694],
positive regulation of vascular associated smooth muscle cell migration [GO:1904754],
Molecular Function:
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
SH3 domain binding [GO:0017124],
PDZ domain binding [GO:0030165],
Rac guanyl-nucleotide exchange factor activity [GO:0030676],
receptor tyrosine kinase binding [GO:0030971],
Rac GTPase binding [GO:0048365],
guanyl-nucleotide exchange factor activity [GO:0005085],
Cellular Component:
nucleolus [GO:0005730],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
stereocilium [GO:0032420],
stereocilium bundle [GO:0032421],
cytoplasm [GO:0005737],