AKAP12

A-kinase anchoring protein 12

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30323895 HeLa Lung Mouse NO

GO terms:

Biological Process:
protein targeting [GO:0006605],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
regulation of protein kinase A signaling [GO:0010738],
positive regulation of protein kinase A signaling [GO:0010739],
response to lipopolysaccharide [GO:0032496],
hepatic stellate cell activation [GO:0035733],
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535],
negative regulation of vascular permeability [GO:0043116],
modulation of synaptic transmission [GO:0050804],
response to electrical stimulus [GO:0051602],
positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
regulation of protein kinase C signaling [GO:0090036],
positive regulation of oligodendrocyte apoptotic process [GO:1900143],
positive regulation of tumor necrosis factor secretion [GO:1904469],
signal transduction [GO:0007165],

Molecular Function:
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
adenylate cyclase binding [GO:0008179],
protein kinase A binding [GO:0051018],
receptor signaling complex scaffold activity [GO:0030159],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
cell cortex [GO:0005938],
neuronal cell body [GO:0043025],
membrane [GO:0016020],