DNM2

dynamin 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
G2/M transition of mitotic cell cycle [GO:0000086],
mitochondrial fission [GO:0000266],
G-protein coupled receptor internalization [GO:0002031],
ventricular septum development [GO:0003281],
dynamin family protein polymerization involved in mitochondrial fission [GO:0003374],
regulation of transcription, DNA-templated [GO:0006355],
Golgi to plasma membrane transport [GO:0006893],
endocytosis [GO:0006897],
receptor-mediated endocytosis [GO:0006898],
phagocytosis [GO:0006909],
signal transduction [GO:0007165],
spermatogenesis [GO:0007283],
response to light stimulus [GO:0009416],
positive regulation of lamellipodium assembly [GO:0010592],
synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185],
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
regulation of axon extension [GO:0030516],
receptor internalization [GO:0031623],
transferrin transport [GO:0033572],
regulation of Rac protein signal transduction [GO:0035020],
aorta development [GO:0035904],
response to cocaine [GO:0042220],
positive regulation of apoptotic process [GO:0043065],
macropinocytosis [GO:0044351],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
positive regulation of transcription, DNA-templated [GO:0045893],
organelle fission [GO:0048285],
synaptic vesicle transport [GO:0048489],
neuron projection morphogenesis [GO:0048812],
positive regulation of phagocytosis [GO:0050766],
regulation of synapse structure or activity [GO:0050803],
regulation of nitric-oxide synthase activity [GO:0050999],
coronary vasculature development [GO:0060976],
membrane organization [GO:0061024],
membrane fusion [GO:0061025],
cellular response to carbon monoxide [GO:0071245],
cellular response to X-ray [GO:0071481],
cellular response to nitric oxide [GO:0071732],
postsynaptic neurotransmitter receptor internalization [GO:0098884],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
negative regulation of non-motile cilium assembly [GO:1902856],
cellular response to dopamine [GO:1903351],
regulation of Golgi organization [GO:1903358],
positive regulation of sodium:potassium-exchanging ATPase activity [GO:1903408],
negative regulation of membrane tubulation [GO:1903526],
positive regulation of clathrin-dependent endocytosis [GO:2000370],
positive regulation of endocytosis [GO:0045807],
synaptic vesicle endocytosis [GO:0048488],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
microtubule binding [GO:0008017],
SH3 domain binding [GO:0017124],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
D2 dopamine receptor binding [GO:0031749],
phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312],
macromolecular complex binding [GO:0044877],
WW domain binding [GO:0050699],
nitric-oxide synthase binding [GO:0050998],
nucleotide binding [GO:0000166],
hydrolase activity [GO:0016787],

Cellular Component:
Golgi membrane [GO:0000139],
phagocytic cup [GO:0001891],
photoreceptor inner segment [GO:0001917],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endosome [GO:0005768],
Golgi apparatus [GO:0005794],
trans-Golgi network [GO:0005802],
centrosome [GO:0005813],
cytosol [GO:0005829],
microtubule [GO:0005874],
plasma membrane [GO:0005886],
clathrin-coated pit [GO:0005905],
focal adhesion [GO:0005925],
postsynaptic density [GO:0014069],
microtubule cytoskeleton [GO:0015630],
membrane [GO:0016020],
lamellipodium [GO:0030027],
axon [GO:0030424],
growth cone [GO:0030426],
midbody [GO:0030496],
endocytic vesicle membrane [GO:0030666],
phagocytic vesicle membrane [GO:0030670],
cytoplasmic vesicle [GO:0031410],
mitochondrial membrane [GO:0031966],
ruffle membrane [GO:0032587],
macromolecular complex [GO:0032991],
dendritic spine [GO:0043197],
dendritic spine head [GO:0044327],
synapse [GO:0045202],
postsynaptic membrane [GO:0045211],
clathrin-coated endocytic vesicle [GO:0045334],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
presynapse [GO:0098793],
postsynaptic endocytic zone membrane [GO:0098844],
glutamatergic synapse [GO:0098978],
cytoskeleton [GO:0005856],
cell junction [GO:0030054],
cell projection [GO:0042995],