DNA2

DNA replication helicase/nuclease 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29449545 HMEC, MRC-5, IMR-90, 293GP, WI-38, HUVEC Human NO
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
DNA replication checkpoint [GO:0000076],
telomere maintenance [GO:0000723],
DNA double-strand break processing [GO:0000729],
DNA replication [GO:0006260],
mitochondrial DNA replication [GO:0006264],
base-excision repair [GO:0006284],
telomere maintenance via semi-conservative replication [GO:0032201],
DNA duplex unwinding [GO:0032508],
DNA replication, Okazaki fragment processing [GO:0033567],
DNA replication, removal of RNA primer [GO:0043137],
mitochondrial DNA repair [GO:0043504],
G-quadruplex DNA unwinding [GO:0044806],
positive regulation of DNA replication [GO:0045740],
replication fork reversal [GO:0071932],
nucleic acid phosphodiester bond hydrolysis [GO:0090305],
t-circle formation [GO:0090656],
regulation of signal transduction by p53 class mediator [GO:1901796],
mitotic telomere maintenance via semi-conservative replication [GO:1902990],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
metabolic process [GO:0008152],

Molecular Function:
DNA binding [GO:0003677],
DNA helicase activity [GO:0003678],
RNA binding [GO:0003723],
helicase activity [GO:0004386],
nuclease activity [GO:0004518],
protein binding [GO:0005515],
ATP binding [GO:0005524],
ATPase activity [GO:0016887],
site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890],
5'-flap endonuclease activity [GO:0017108],
single-stranded DNA-dependent ATP-dependent DNA helicase activity [GO:0017116],
5'-3' DNA helicase activity [GO:0043139],
metal ion binding [GO:0046872],
4 iron, 4 sulfur cluster binding [GO:0051539],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
endonuclease activity [GO:0004519],
hydrolase activity [GO:0016787],
iron-sulfur cluster binding [GO:0051536],

Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
gamma DNA polymerase complex [GO:0005760],
mitochondrial nucleoid [GO:0042645],