DMD

dystrophin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
regulation of heart rate [GO:0002027],
cytoskeleton organization [GO:0007010],
muscle organ development [GO:0007517],
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880],
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881],
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809],
regulation of skeletal muscle contraction [GO:0014819],
muscle filament sliding [GO:0030049],
negative regulation of peptidyl-serine phosphorylation [GO:0033137],
cellular protein localization [GO:0034613],
cellular macromolecular complex assembly [GO:0034622],
maintenance of blood-brain barrier [GO:0035633],
response to muscle stretch [GO:0035994],
peptide biosynthetic process [GO:0043043],
muscle cell cellular homeostasis [GO:0046716],
muscle fiber development [GO:0048747],
cardiac muscle contraction [GO:0060048],
regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314],
cardiac muscle cell action potential [GO:0086001],
regulation of voltage-gated calcium channel activity [GO:1901385],
negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083],
positive regulation of sodium ion transmembrane transporter activity [GO:2000651],
positive regulation of cell-matrix adhesion [GO:0001954],
regulation of transcription, DNA-templated [GO:0006355],
skeletal muscle tissue development [GO:0007519],
establishment of blood-nerve barrier [GO:0008065],
regulation of gene expression [GO:0010468],
positive regulation of neuron projection development [GO:0010976],
myotube cell development [GO:0014904],
olfactory nerve structural organization [GO:0021629],
regulation of membrane potential [GO:0042391],
neurotransmitter receptor metabolic process [GO:0045213],
positive regulation of neuron differentiation [GO:0045666],
nucleus localization [GO:0051647],
establishment of glial blood-brain barrier [GO:0060857],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
regulation of cellular response to growth factor stimulus [GO:0090287],

Molecular Function:
dystroglycan binding [GO:0002162],
actin binding [GO:0003779],
structural constituent of cytoskeleton [GO:0005200],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
structural constituent of muscle [GO:0008307],
myosin binding [GO:0017022],
vinculin binding [GO:0017166],
nitric-oxide synthase binding [GO:0050998],
metal ion binding [GO:0046872],

Cellular Component:
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
cell surface [GO:0009986],
dystrophin-associated glycoprotein complex [GO:0016010],
syntrophin complex [GO:0016013],
lateral plasma membrane [GO:0016328],
Z disc [GO:0030018],
cell-substrate junction [GO:0030055],
filopodium [GO:0030175],
filopodium membrane [GO:0031527],
macromolecular complex [GO:0032991],
sarcolemma [GO:0042383],
costamere [GO:0043034],
neuron projection terminus [GO:0044306],
membrane raft [GO:0045121],
synapse [GO:0045202],
postsynaptic membrane [GO:0045211],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
membrane [GO:0016020],
cell junction [GO:0030054],