discs large MAGUK scaffold protein 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
epithelial to mesenchymal transition [GO:0001837],
signal transduction [GO:0007165],
negative regulation of cell proliferation [GO:0008285],
maintenance of cell polarity [GO:0030011],
negative regulation of cell migration [GO:0030336],
polarized epithelial cell differentiation [GO:0030859],
midbrain development [GO:0030901],
negative regulation of hippo signaling [GO:0035331],
positive regulation of hippo signaling [GO:0035332],
intracellular signal transduction [GO:0035556],
negative regulation of T cell proliferation [GO:0042130],
regulation of apoptotic process [GO:0042981],
apical protein localization [GO:0045176],
zonula adherens assembly [GO:0045186],
establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197],
positive regulation of smoothened signaling pathway [GO:0045880],
positive regulation of synapse assembly [GO:0051965],
epithelial tube branching involved in lung morphogenesis [GO:0060441],
positive regulation of dendritic spine development [GO:0060999],
macromolecular complex assembly [GO:0065003],
protein localization to adherens junction [GO:0071896],
metanephric collecting duct development [GO:0072205],
cell-cell adhesion [GO:0098609],

Molecular Function:
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
cytoskeletal protein binding [GO:0008092],
receptor signaling complex scaffold activity [GO:0030159],

Cellular Component:
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
postsynaptic density [GO:0014069],
cell junction [GO:0030054],
ciliary basal body [GO:0036064],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
cell projection [GO:0042995],
synapse [GO:0045202],