discs large MAGUK scaffold protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
MAPK cascade [GO:0000165],
branching involved in ureteric bud morphogenesis [GO:0001658],
immunological synapse formation [GO:0001771],
endothelial cell proliferation [GO:0001935],
lens development in camera-type eye [GO:0002088],
T cell cytokine production [GO:0002369],
protein dephosphorylation [GO:0006470],
actin filament organization [GO:0007015],
mitotic cell cycle checkpoint [GO:0007093],
establishment or maintenance of cell polarity [GO:0007163],
chemical synaptic transmission [GO:0007268],
positive regulation of cell proliferation [GO:0008284],
regulation of cell shape [GO:0008360],
embryo development [GO:0009790],
viral process [GO:0016032],
peristalsis [GO:0030432],
positive regulation of actin filament polymerization [GO:0030838],
cortical actin cytoskeleton organization [GO:0030866],
astral microtubule organization [GO:0030953],
membrane raft organization [GO:0031579],
regulation of myelination [GO:0031641],
activation of protein kinase activity [GO:0032147],
cellular protein complex localization [GO:0034629],
T cell activation [GO:0042110],
negative regulation of T cell proliferation [GO:0042130],
regulation of membrane potential [GO:0042391],
amyloid precursor protein metabolic process [GO:0042982],
receptor clustering [GO:0043113],
positive regulation of potassium ion transport [GO:0043268],
cortical microtubule organization [GO:0043622],
establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197],
negative regulation of mitotic cell cycle [GO:0045930],
GMP metabolic process [GO:0046037],
GDP metabolic process [GO:0046710],
reproductive structure development [GO:0048608],
embryonic skeletal system morphogenesis [GO:0048704],
smooth muscle tissue development [GO:0048745],
negative regulation of epithelial cell proliferation [GO:0050680],
establishment of centrosome localization [GO:0051660],
negative regulation of protein kinase B signaling [GO:0051898],
hard palate development [GO:0060022],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
bicellular tight junction assembly [GO:0070830],
protein localization to plasma membrane [GO:0072659],
receptor localization to synapse [GO:0097120],
cell-cell adhesion [GO:0098609],
regulation of ventricular cardiac muscle cell action potential [GO:0098911],
maintenance of postsynaptic density structure [GO:0099562],
neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645],
regulation of NIK/NF-kappaB signaling [GO:1901222],
regulation of sodium ion transmembrane transport [GO:1902305],
regulation of protein localization to synapse [GO:1902473],
positive regulation of protein localization to plasma membrane [GO:1903078],
regulation of potassium ion import [GO:1903286],
negative regulation of p38MAPK cascade [GO:1903753],
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903760],
regulation of potassium ion export across plasma membrane [GO:1903764],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
ureteric bud development [GO:0001657],
protein localization [GO:0008104],
regulation of protein localization [GO:0032880],
positive regulation of multicellular organism growth [GO:0040018],
positive regulation of developmental growth [GO:0048639],
tissue morphogenesis [GO:0048729],

Molecular Function:
guanylate kinase activity [GO:0004385],
phosphoprotein phosphatase activity [GO:0004721],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
cytoskeletal protein binding [GO:0008092],
potassium channel regulator activity [GO:0015459],
protein kinase binding [GO:0019901],
phosphatase binding [GO:0019902],
mitogen-activated protein kinase kinase binding [GO:0031434],
ion channel binding [GO:0044325],
cadherin binding [GO:0045296],
binding, bridging [GO:0060090],
L27 domain binding [GO:0097016],
structural constituent of postsynaptic density [GO:0098919],
kinesin binding [GO:0019894],
kinase binding [GO:0019900],
PDZ domain binding [GO:0030165],
ionotropic glutamate receptor binding [GO:0035255],

Cellular Component:
immunological synapse [GO:0001772],
basement membrane [GO:0005604],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
microtubule [GO:0005874],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
bicellular tight junction [GO:0005923],
ionotropic glutamate receptor complex [GO:0008328],
cytoplasmic side of plasma membrane [GO:0009898],
intercalated disc [GO:0014704],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
lateral plasma membrane [GO:0016328],
cell junction [GO:0030054],
cell projection membrane [GO:0031253],
neuromuscular junction [GO:0031594],
node of Ranvier [GO:0033268],
myelin sheath abaxonal region [GO:0035748],
sarcolemma [GO:0042383],
neuron projection [GO:0043005],
lateral loop [GO:0043219],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
MPP7-DLG1-LIN7 complex [GO:0097025],
synaptic membrane [GO:0097060],
postsynaptic density membrane [GO:0098839],
glutamatergic synapse [GO:0098978],
microvillus [GO:0005902],
adherens junction [GO:0005912],
basal plasma membrane [GO:0009925],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
T-tubule [GO:0030315],
dendrite [GO:0030425],
paranode region of axon [GO:0033270],
presynaptic membrane [GO:0042734],
synapse [GO:0045202],