ajuba LIM protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Saos-2 Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
response to hypoxia [GO:0001666],
regulation of transcription, DNA-templated [GO:0006355],
cytoskeleton organization [GO:0007010],
cell cycle [GO:0007049],
cell adhesion [GO:0007155],
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339],
lamellipodium assembly [GO:0030032],
regulation of cell migration [GO:0030334],
gene silencing by RNA [GO:0031047],
positive regulation of cellular biosynthetic process [GO:0031328],
positive regulation of protein complex assembly [GO:0031334],
negative regulation of kinase activity [GO:0033673],
positive regulation of kinase activity [GO:0033674],
cellular protein localization [GO:0034613],
gene silencing by miRNA [GO:0035195],
wound healing, spreading of epidermal cells [GO:0035313],
negative regulation of hippo signaling [GO:0035331],
regulation of GTPase activity [GO:0043087],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of MAP kinase activity [GO:0043406],
glycerophospholipid biosynthetic process [GO:0046474],
focal adhesion assembly [GO:0048041],
regulation of cellular response to hypoxia [GO:1900037],
positive regulation of gene silencing by miRNA [GO:2000637],
G2/M transition of mitotic cell cycle [GO:0000086],

Molecular Function:
chromatin binding [GO:0003682],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
alpha-catenin binding [GO:0045294],
metal ion binding [GO:0046872],
actin filament binding [GO:0051015],

Cellular Component:
cytoplasmic mRNA processing body [GO:0000932],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
adherens junction [GO:0005912],
focal adhesion [GO:0005925],
membrane [GO:0016020],
lamellipodium [GO:0030027],
cell junction [GO:0030054],
microtubule organizing center [GO:0005815],