DLC1 Rho GTPase activating protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
23853104 Huh7, HepG2 Human NO

GO terms:

Biological Process:
neural tube closure [GO:0001843],
heart morphogenesis [GO:0003007],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
signal transduction [GO:0007165],
negative regulation of cell proliferation [GO:0008285],
regulation of cell shape [GO:0008360],
hindbrain morphogenesis [GO:0021575],
actin cytoskeleton organization [GO:0030036],
negative regulation of cell migration [GO:0030336],
forebrain development [GO:0030900],
regulation of actin cytoskeleton organization [GO:0032956],
regulation of Rho protein signal transduction [GO:0035023],
negative regulation of Rho protein signal transduction [GO:0035024],
positive regulation of protein dephosphorylation [GO:0035307],
positive regulation of GTPase activity [GO:0043547],
focal adhesion assembly [GO:0048041],
regulation of small GTPase mediated signal transduction [GO:0051056],
negative regulation of stress fiber assembly [GO:0051497],
negative regulation of focal adhesion assembly [GO:0051895],
positive regulation of execution phase of apoptosis [GO:1900119],
cytoskeleton organization [GO:0007010],
activation of phospholipase C activity [GO:0007202],

Molecular Function:
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
lipid binding [GO:0008289],
SH2 domain binding [GO:0042169],
vinculin binding [GO:0017166],
phospholipase binding [GO:0043274],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
caveola [GO:0005901],
focal adhesion [GO:0005925],
cortical actin cytoskeleton [GO:0030864],
ruffle membrane [GO:0032587],
membrane raft [GO:0045121],
stress fiber [GO:0001725],
actin filament [GO:0005884],
membrane [GO:0016020],
cell junction [GO:0030054],