DICER1

dicer 1, ribonuclease III

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
18591425 MEF Mouse NO
23851498 Prostate gland Mouse NO
25361944 Primary mesenchymal stem cells derived from bone marrow Human NO
26990999 WI‐38, IMR‐9, IDH4 Liver Human, mouse NO
29724992 Primary mesenchymal stem cells derived from bone marrow, NCI-H929, OPM-2, KMS-12-BM Human NO
33495462 SW 1353 Human No

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
apoptotic DNA fragmentation [GO:0006309],
miRNA metabolic process [GO:0010586],
negative regulation of Schwann cell proliferation [GO:0010626],
negative regulation of gene expression [GO:0010629],
positive regulation of Schwann cell differentiation [GO:0014040],
nerve development [GO:0021675],
production of siRNA involved in RNA interference [GO:0030422],
targeting of mRNA for destruction involved in RNA interference [GO:0030423],
pre-miRNA processing [GO:0031054],
positive regulation of myelination [GO:0031643],
peripheral nervous system myelin formation [GO:0032290],
negative regulation of tumor necrosis factor production [GO:0032720],
conversion of ds siRNA to ss siRNA involved in RNA interference [GO:0033168],
siRNA loading onto RISC involved in RNA interference [GO:0035087],
tube formation [GO:0035148],
production of miRNAs involved in gene silencing by miRNA [GO:0035196],
miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280],
conversion of ds siRNA to ss siRNA [GO:0036404],
NIK/NF-kappaB signaling [GO:0038061],
neuron projection morphogenesis [GO:0048812],
RNA phosphodiester bond hydrolysis [GO:0090501],
RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502],
meiotic spindle organization [GO:0000212],
angiogenesis [GO:0001525],
trophectodermal cell proliferation [GO:0001834],
regulation of protein phosphorylation [GO:0001932],
hair follicle development [GO:0001942],
RNA processing [GO:0006396],
spermatogonial cell division [GO:0007284],
cell proliferation [GO:0008283],
regulation of Notch signaling pathway [GO:0008593],
post-embryonic development [GO:0009791],
zygote asymmetric cell division [GO:0010070],
regulation of gene expression [GO:0010468],
positive regulation of gene expression [GO:0010628],
regulation of muscle cell apoptotic process [GO:0010660],
myoblast differentiation involved in skeletal muscle regeneration [GO:0014835],
rRNA catabolic process [GO:0016075],
RNA interference [GO:0016246],
stem cell population maintenance [GO:0019827],
spinal cord motor neuron differentiation [GO:0021522],
olfactory bulb interneuron differentiation [GO:0021889],
cerebral cortex development [GO:0021987],
lung development [GO:0030324],
embryonic limb morphogenesis [GO:0030326],
gene silencing by RNA [GO:0031047],
hair follicle morphogenesis [GO:0031069],
pericentric heterochromatin assembly [GO:0031508],
regulation of myelination [GO:0031641],
embryonic hindlimb morphogenesis [GO:0035116],
multicellular organism growth [GO:0035264],
regulation of odontogenesis of dentin-containing tooth [GO:0042487],
regulation of viral genome replication [GO:0045069],
regulation of regulatory T cell differentiation [GO:0045589],
regulation of cell differentiation [GO:0045595],
regulation of neuron differentiation [GO:0045664],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
mRNA stabilization [GO:0048255],
spleen development [GO:0048536],
digestive tract development [GO:0048565],
reproductive structure development [GO:0048608],
regulation of oligodendrocyte differentiation [GO:0048713],
epidermis morphogenesis [GO:0048730],
branching morphogenesis of an epithelial tube [GO:0048754],
anatomical structure development [GO:0048856],
regulation of inflammatory response [GO:0050727],
regulation of neurogenesis [GO:0050767],
cartilage development [GO:0051216],
spindle assembly [GO:0051225],
regulation of RNA metabolic process [GO:0051252],
defense response to virus [GO:0051607],
regulation of cell cycle [GO:0051726],
cardiac muscle cell development [GO:0055013],
inner ear receptor cell development [GO:0060119],
negative regulation of glial cell proliferation [GO:0060253],
intestinal epithelial cell development [GO:0060576],
cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309],
ganglion development [GO:0061548],
regulation of enamel mineralization [GO:0070173],
hair follicle cell proliferation [GO:0071335],
regulation of miRNA metabolic process [GO:2000628],
positive regulation of miRNA metabolic process [GO:2000630],
regulation of stem cell differentiation [GO:2000736],

Molecular Function:
DNA binding [GO:0003677],
RNA binding [GO:0003723],
double-stranded RNA binding [GO:0003725],
helicase activity [GO:0004386],
endoribonuclease activity [GO:0004521],
ribonuclease III activity [GO:0004525],
deoxyribonuclease I activity [GO:0004530],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein domain specific binding [GO:0019904],
siRNA binding [GO:0035197],
metal ion binding [GO:0046872],
pre-miRNA binding [GO:0070883],
nucleotide binding [GO:0000166],
nuclease activity [GO:0004518],
endonuclease activity [GO:0004519],
hydrolase activity [GO:0016787],
endoribonuclease activity, producing 5'-phosphomonoesters [GO:0016891],
miRNA binding [GO:0035198],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endoplasmic reticulum-Golgi intermediate compartment [GO:0005793],
cytosol [GO:0005829],
RISC complex [GO:0016442],
dendrite [GO:0030425],
growth cone [GO:0030426],
ARC complex [GO:0033167],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
RISC-loading complex [GO:0070578],
axon [GO:0030424],