DHCR7

7-dehydrocholesterol reductase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
blood vessel development [GO:0001568],
cholesterol biosynthetic process [GO:0006695],
post-embryonic development [GO:0009791],
sterol biosynthetic process [GO:0016126],
brassinosteroid biosynthetic process [GO:0016132],
cell differentiation [GO:0030154],
lung development [GO:0030324],
cholesterol biosynthetic process via desmosterol [GO:0033489],
cholesterol biosynthetic process via lathosterol [GO:0033490],
multicellular organism growth [GO:0035264],
regulation of cell proliferation [GO:0042127],
regulation of cholesterol biosynthetic process [GO:0045540],
oxidation-reduction process [GO:0055114],
lipid metabolic process [GO:0006629],
steroid biosynthetic process [GO:0006694],
steroid metabolic process [GO:0008202],
cholesterol metabolic process [GO:0008203],

Molecular Function:
protein binding [GO:0005515],
sterol delta7 reductase activity [GO:0009918],
oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627],
7-dehydrocholesterol reductase activity [GO:0047598],
NADP binding [GO:0050661],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628],

Cellular Component:
nuclear outer membrane [GO:0005640],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
membrane [GO:0016020],
integral component of endoplasmic reticulum membrane [GO:0030176],
integral component of membrane [GO:0016021],
intracellular membrane-bounded organelle [GO:0043231],