DHCR24

24-dehydrocholesterol reductase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
15577914 WI-38, primary fibroblasts derived from rat Human, rat NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
cholesterol biosynthetic process [GO:0006695],
apoptotic process [GO:0006915],
response to oxidative stress [GO:0006979],
cell cycle arrest [GO:0007050],
Ras protein signal transduction [GO:0007265],
protein localization [GO:0008104],
steroid metabolic process [GO:0008202],
negative regulation of cell proliferation [GO:0008285],
response to hormone [GO:0009725],
tissue development [GO:0009888],
male genitalia development [GO:0030539],
plasminogen activation [GO:0031639],
cholesterol biosynthetic process via desmosterol [GO:0033489],
cholesterol biosynthetic process via lathosterol [GO:0033490],
amyloid precursor protein catabolic process [GO:0042987],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
skin development [GO:0043588],
oxidation-reduction process [GO:0055114],
membrane organization [GO:0061024],
regulation of neuron death [GO:1901214],
lipid metabolic process [GO:0006629],
steroid biosynthetic process [GO:0006694],
cholesterol metabolic process [GO:0008203],
sterol metabolic process [GO:0016125],
sterol biosynthetic process [GO:0016126],

Molecular Function:
delta24(24-1) sterol reductase activity [GO:0000246],
protein binding [GO:0005515],
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628],
enzyme binding [GO:0019899],
peptide antigen binding [GO:0042605],
delta24-sterol reductase activity [GO:0050614],
FAD binding [GO:0071949],
oxidoreductase activity [GO:0016491],
flavin adenine dinucleotide binding [GO:0050660],

Cellular Component:
Golgi membrane [GO:0000139],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
Golgi apparatus [GO:0005794],