diacylglycerol O-acyltransferase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA261 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30912009 Adipose tissue Human NO

GO terms:

Biological Process:
glycerol metabolic process [GO:0006071],
lipid metabolic process [GO:0006629],
monoacylglycerol biosynthetic process [GO:0006640],
diacylglycerol biosynthetic process [GO:0006651],
positive regulation of triglyceride biosynthetic process [GO:0010867],
triglyceride biosynthetic process [GO:0019432],
lipid storage [GO:0019915],
low-density lipoprotein particle clearance [GO:0034383],
long-chain fatty-acyl-CoA metabolic process [GO:0035336],
cellular triglyceride homeostasis [GO:0035356],
cholesterol homeostasis [GO:0042632],
positive regulation of gluconeogenesis [GO:0045722],
negative regulation of fatty acid oxidation [GO:0046322],
diacylglycerol metabolic process [GO:0046339],
regulation of lipoprotein metabolic process [GO:0050746],
fatty acid homeostasis [GO:0055089],
fat pad development [GO:0060613],
cellular response to oleic acid [GO:0071400],
regulation of cholesterol metabolic process [GO:0090181],
regulation of plasma lipoprotein particle levels [GO:0097006],
acylglycerol acyl-chain remodeling [GO:0036155],
retinol metabolic process [GO:0042572],

Molecular Function:
2-acylglycerol O-acyltransferase activity [GO:0003846],
diacylglycerol O-acyltransferase activity [GO:0004144],
O-acyltransferase activity [GO:0008374],
transferase activity [GO:0016740],
transferase activity, transferring acyl groups [GO:0016746],
transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747],
protein homodimerization activity [GO:0042803],
retinol O-fatty-acyltransferase activity [GO:0050252],
protein binding [GO:0005515],

Cellular Component:
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
lipid particle [GO:0005811],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
integral component of endoplasmic reticulum membrane [GO:0030176],
intracellular membrane-bounded organelle [GO:0043231],
perinuclear region of cytoplasm [GO:0048471],
perinuclear endoplasmic reticulum membrane [GO:1990578],