DEP domain containing 5, GATOR1 subcomplex subunit

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
regulation of autophagy [GO:0010506],
negative regulation of TOR signaling [GO:0032007],
cellular response to amino acid starvation [GO:0034198],
intracellular signal transduction [GO:0035556],
positive regulation of GTPase activity [GO:0043547],
negative regulation of TORC1 signaling [GO:1904262],

Molecular Function:
GTPase activator activity [GO:0005096],
macromolecular complex binding [GO:0044877],

Cellular Component:
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
cytosol [GO:0005829],
Cul3-RING ubiquitin ligase complex [GO:0031463],
perinuclear region of cytoplasm [GO:0048471],
Iml1 complex [GO:1990130],
cytoplasm [GO:0005737],
membrane [GO:0016020],