AHR
aryl hydrocarbon receptor
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
Pubmed ID | Cell line | Tissue | Source | High-throughput |
30285098 | HT-1080 | Human | YES | |
31812582 | Primary stem cells derived from bone marrow | Mouse | NO | |
31945125 | Primary astrocytes derived from brain | Human | YES | |
Status in senescence: Down-regulated | ||||
Pubmed ID | Cell line | Tissue | Source | High-throughput |
31983656 | MSC | Human | YES | |
32029712 | Primary synovial fibroblast | Human | YES |
GO terms:
Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
blood vessel development [GO:0001568],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription from RNA polymerase II promoter [GO:0006366],
xenobiotic metabolic process [GO:0006805],
apoptotic process [GO:0006915],
cell cycle [GO:0007049],
response to xenobiotic stimulus [GO:0009410],
response to toxic substance [GO:0009636],
regulation of gene expression [GO:0010468],
cAMP-mediated signaling [GO:0019933],
intracellular receptor signaling pathway [GO:0030522],
regulation of B cell proliferation [GO:0030888],
circadian regulation of gene expression [GO:0032922],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
cellular response to cAMP [GO:0071320],
cellular response to forskolin [GO:1904322],
cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613],
cell morphogenesis [GO:0000902],
ovarian follicle development [GO:0001541],
patterning of blood vessels [GO:0001569],
B cell homeostasis [GO:0001782],
liver development [GO:0001889],
B-1 B cell homeostasis [GO:0001922],
blood vessel remodeling [GO:0001974],
lymphocyte homeostasis [GO:0002260],
immune system process [GO:0002376],
negative regulation of systemic arterial blood pressure [GO:0003085],
cardiac left ventricle morphogenesis [GO:0003214],
circumferential growth involved in left ventricle morphogenesis [GO:0003243],
blood circulation [GO:0008015],
regulation of blood pressure [GO:0008217],
negative regulation of alkaline phosphatase activity [GO:0010693],
response to organic cyclic compound [GO:0014070],
B cell differentiation [GO:0030183],
prostate gland development [GO:0030850],
negative regulation of osteoblast proliferation [GO:0033689],
embryonic hemopoiesis [GO:0035162],
post-embryonic hemopoiesis [GO:0035166],
positive regulation of growth rate [GO:0040010],
camera-type eye development [GO:0043010],
T cell homeostasis [GO:0043029],
negative regulation of osteoblast differentiation [GO:0045668],
positive regulation of cell size [GO:0045793],
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899],
negative regulation of vasoconstriction [GO:0045906],
rhythmic process [GO:0048511],
blood vessel morphogenesis [GO:0048514],
spleen development [GO:0048536],
reproductive structure development [GO:0048608],
gland development [GO:0048732],
smooth muscle tissue development [GO:0048745],
regulation of heart growth [GO:0060420],
negative regulation of necrotic cell death [GO:0060547],
venous blood vessel development [GO:0060841],
kidney morphogenesis [GO:0060993],
common bile duct development [GO:0061009],
glomerulus morphogenesis [GO:0072102],
negative regulation of calcium ion transmembrane transport [GO:1903170],
cellular response to 3-methylcholanthrene [GO:1904682],
negative regulation of DNA biosynthetic process [GO:2000279],
Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
core promoter proximal region sequence-specific DNA binding [GO:0000987],
TFIID-class transcription factor binding [GO:0001094],
transcription coactivator binding [GO:0001223],
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding [GO:0004879],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
TBP-class protein binding [GO:0017025],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],
Hsp90 protein binding [GO:0051879],
E-box binding [GO:0070888],
sequence-specific double-stranded DNA binding [GO:1990837],
toxic substance binding [GO:0015643],
aryl hydrocarbon receptor binding [GO:0017162],
identical protein binding [GO:0042802],
sequence-specific DNA binding [GO:0043565],
protein dimerization activity [GO:0046983],
chaperone binding [GO:0051087],
Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
macromolecular complex [GO:0032991],
cytosolic aryl hydrocarbon receptor complex [GO:0034752],
aryl hydrocarbon receptor complex [GO:0034751],
nuclear aryl hydrocarbon receptor complex [GO:0034753],