death effector domain containing 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
apoptotic process [GO:0006915],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
apoptotic nuclear changes [GO:0030262],
regulation of apoptotic process [GO:0042981],
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238],
RNA processing [GO:0006396],
rRNA catabolic process [GO:0016075],
cellular homeostasis [GO:0019725],
intracellular signal transduction [GO:0035556],
negative regulation of transcription, DNA-templated [GO:0045892],

Molecular Function:
DNA binding [GO:0003677],
protein binding [GO:0005515],
receptor signaling complex scaffold activity [GO:0030159],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],