DDX5

DEAD-box helicase 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
alternative mRNA splicing, via spliceosome [GO:0000380],
regulation of alternative mRNA splicing, via spliceosome [GO:0000381],
mRNA splicing, via spliceosome [GO:0000398],
nuclear-transcribed mRNA catabolic process [GO:0000956],
epithelial to mesenchymal transition [GO:0001837],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
mRNA transcription [GO:0009299],
BMP signaling pathway [GO:0030509],
intracellular estrogen receptor signaling pathway [GO:0030520],
androgen receptor signaling pathway [GO:0030521],
positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517],
regulation of viral genome replication [GO:0045069],
myoblast differentiation [GO:0045445],
regulation of osteoblast differentiation [GO:0045667],
rhythmic process [GO:0048511],
regulation of androgen receptor signaling pathway [GO:0060765],
pri-miRNA transcription from RNA polymerase II promoter [GO:0061614],
intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332],
regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902893],
positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800],
regulation of skeletal muscle cell differentiation [GO:2001014],
mRNA processing [GO:0006397],
protein import into nucleus [GO:0006606],
circadian rhythm [GO:0007623],
RNA splicing [GO:0008380],
positive regulation of transcription, DNA-templated [GO:0045893],

Molecular Function:
RNA binding [GO:0003723],
RNA helicase activity [GO:0003724],
mRNA 3'-UTR binding [GO:0003730],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
enzyme binding [GO:0019899],
MH2 domain binding [GO:0035500],
pre-mRNA binding [GO:0036002],
ribonucleoprotein complex binding [GO:0043021],
SMAD binding [GO:0046332],
calcium-dependent protein binding [GO:0048306],
androgen receptor binding [GO:0050681],
R-SMAD binding [GO:0070412],
primary miRNA binding [GO:0070878],
promoter-specific chromatin binding [GO:1990841],
nucleotide binding [GO:0000166],
nucleic acid binding [GO:0003676],
transcription cofactor activity [GO:0003712],
helicase activity [GO:0004386],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
membrane [GO:0016020],
extracellular exosome [GO:0070062],
catalytic step 2 spliceosome [GO:0071013],
ribonucleoprotein complex [GO:1990904],
spliceosomal complex [GO:0005681],