DDRGK1

DDRGK domain containing 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA37 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
positive regulation of cell proliferation [GO:0008284],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of cell migration [GO:0030335],
negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
regulation of intracellular estrogen receptor signaling pathway [GO:0033146],
response to endoplasmic reticulum stress [GO:0034976],
negative regulation of apoptotic process [GO:0043066],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
cartilage development [GO:0051216],
positive regulation of proteasomal protein catabolic process [GO:1901800],
positive regulation of cell cycle G1/S phase transition [GO:1902808],
positive regulation of I-kappaB phosphorylation [GO:1903721],
positive regulation of metallopeptidase activity [GO:1905050],
positive regulation of protein localization to endoplasmic reticulum [GO:1905552],
protein K69-linked ufmylation [GO:1990592],

Molecular Function:
RNA polymerase II repressing transcription factor binding [GO:0001103],
protein binding [GO:0005515],
ubiquitin-like protein ligase binding [GO:0044389],

Cellular Component:
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],