ABCA7

ATP binding cassette subfamily A member 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES

GO terms:

Biological Process:
lipid transport [GO:0006869],
phagocytosis [GO:0006909],
memory [GO:0007613],
positive regulation of cholesterol efflux [GO:0010875],
peptide cross-linking [GO:0018149],
cholesterol efflux [GO:0033344],
phospholipid efflux [GO:0033700],
beta-amyloid formation [GO:0034205],
high-density lipoprotein particle assembly [GO:0034380],
protein localization to nucleus [GO:0034504],
apolipoprotein A-I-mediated signaling pathway [GO:0038027],
negative regulation of amyloid precursor protein biosynthetic process [GO:0042985],
plasma membrane raft organization [GO:0044857],
phospholipid translocation [GO:0045332],
negative regulation of endocytosis [GO:0045806],
positive regulation of phagocytosis [GO:0050766],
transmembrane transport [GO:0055085],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of beta-amyloid clearance [GO:1900223],
positive regulation of engulfment of apoptotic cell [GO:1901076],
negative regulation of beta-amyloid formation [GO:1902430],
regulation of amyloid precursor protein catabolic process [GO:1902991],
positive regulation of phospholipid efflux [GO:1902995],
positive regulation of protein localization to cell surface [GO:2000010],

Molecular Function:
lipid transporter activity [GO:0005319],
ATP binding [GO:0005524],
ATPase activity [GO:0016887],
apolipoprotein A-I receptor activity [GO:0034188],
ATPase activity, coupled to transmembrane movement of substances [GO:0042626],
phosphatidylcholine-translocating ATPase activity [GO:0090554],
phosphatidylserine-translocating ATPase activity [GO:0090556],
nucleotide binding [GO:0000166],
protein binding [GO:0005515],
phospholipid transporter activity [GO:0005548],

Cellular Component:
Golgi membrane [GO:0000139],
phagocytic cup [GO:0001891],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
early endosome membrane [GO:0031901],
ruffle membrane [GO:0032587],
intracellular membrane-bounded organelle [GO:0043231],
glial cell projection [GO:0097386],
intracellular [GO:0005622],
cytoplasm [GO:0005737],
endosome [GO:0005768],
membrane [GO:0016020],
apical plasma membrane [GO:0016324],
cell projection [GO:0042995],