DARS2

aspartyl-tRNA synthetase 2, mitochondrial

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
tRNA aminoacylation for protein translation [GO:0006418],
tRNA aminoacylation [GO:0043039],
mitochondrial asparaginyl-tRNA aminoacylation [GO:0070145],
translation [GO:0006412],

Molecular Function:
tRNA binding [GO:0000049],
aspartate-tRNA ligase activity [GO:0004815],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein homodimerization activity [GO:0042803],
aspartate-tRNA(Asn) ligase activity [GO:0050560],
nucleotide binding [GO:0000166],
nucleic acid binding [GO:0003676],
aminoacyl-tRNA ligase activity [GO:0004812],
ligase activity [GO:0016874],

Cellular Component:
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
cytoplasm [GO:0005737],