DAPK3

death associated protein kinase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
chromatin organization [GO:0006325],
regulation of transcription, DNA-templated [GO:0006355],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
regulation of smooth muscle contraction [GO:0006940],
regulation of mitotic nuclear division [GO:0007088],
regulation of mitotic cell cycle [GO:0007346],
regulation of cell shape [GO:0008360],
regulation of autophagy [GO:0010506],
negative regulation of translation [GO:0017148],
neuron differentiation [GO:0030182],
positive regulation of cell migration [GO:0030335],
intracellular signal transduction [GO:0035556],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
regulation of myosin II filament organization [GO:0043519],
protein autophosphorylation [GO:0046777],
regulation of focal adhesion assembly [GO:0051893],
cellular response to interferon-gamma [GO:0071346],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
apoptotic signaling pathway [GO:0097190],
regulation of cell motility [GO:2000145],
regulation of actin cytoskeleton reorganization [GO:2000249],
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241],
phosphorylation [GO:0016310],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
cAMP response element binding protein binding [GO:0008140],
Rho GTPase binding [GO:0017048],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
leucine zipper domain binding [GO:0043522],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
actin filament [GO:0005884],
PML body [GO:0016605],
membrane raft [GO:0045121],
chromosome, centromeric region [GO:0000775],
chromosome [GO:0005694],
cytoskeleton [GO:0005856],