DAPK1

death associated protein kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
regulation of autophagy [GO:0010506],
positive regulation of autophagy [GO:0010508],
negative regulation of translation [GO:0017148],
intracellular signal transduction [GO:0035556],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
protein autophosphorylation [GO:0046777],
cellular response to interferon-gamma [GO:0071346],
cellular response to hydroperoxide [GO:0071447],
apoptotic signaling pathway [GO:0097190],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
regulation of translation [GO:0006417],
signal transduction [GO:0007165],
phosphorylation [GO:0016310],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
calmodulin-dependent protein kinase activity [GO:0004683],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
GTP binding [GO:0005525],
syntaxin-1 binding [GO:0017075],
identical protein binding [GO:0042802],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
actin cytoskeleton [GO:0015629],
cytosol [GO:0005829],