DAB2IP

DAB2 interacting protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
activation of MAPKKK activity [GO:0000185],
angiogenesis [GO:0001525],
negative regulation of protein phosphorylation [GO:0001933],
immune system process [GO:0002376],
apoptotic process [GO:0006915],
inflammatory response [GO:0006954],
response to unfolded protein [GO:0006986],
cell cycle [GO:0007049],
signal transduction [GO:0007165],
I-kappaB phosphorylation [GO:0007252],
activation of JUN kinase activity [GO:0007257],
multicellular organism development [GO:0007275],
negative regulation of cell proliferation [GO:0008285],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
negative regulation of endothelial cell migration [GO:0010596],
negative regulation of epithelial cell migration [GO:0010633],
negative regulation of epithelial to mesenchymal transition [GO:0010719],
positive regulation of neuron projection development [GO:0010976],
negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067],
negative regulation of angiogenesis [GO:0016525],
cell motility involved in cerebral cortex radial glia guided migration [GO:0021814],
layer formation in cerebral cortex [GO:0021819],
negative regulation of cell growth [GO:0030308],
negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948],
positive regulation of protein complex assembly [GO:0031334],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
negative regulation of toll-like receptor 4 signaling pathway [GO:0034144],
negative regulation of GTPase activity [GO:0034260],
tube formation [GO:0035148],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324],
reelin-mediated signaling pathway [GO:0038026],
regulation of growth [GO:0040008],
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059],
positive regulation of apoptotic process [GO:0043065],
regulation of GTPase activity [GO:0043087],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124],
regulation of protein complex assembly [GO:0043254],
negative regulation of MAP kinase activity [GO:0043407],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of JUN kinase activity [GO:0043507],
negative regulation of phosphatidylinositol 3-kinase activity [GO:0043553],
cellular protein catabolic process [GO:0044257],
innate immune response [GO:0045087],
positive regulation of protein catabolic process [GO:0045732],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
negative regulation of Ras protein signal transduction [GO:0046580],
negative regulation of fibroblast proliferation [GO:0048147],
neuron projection morphogenesis [GO:0048812],
negative regulation of epithelial cell proliferation [GO:0050680],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
negative regulation of G0 to G1 transition [GO:0070317],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
positive regulation of cell cycle arrest [GO:0071158],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to epidermal growth factor stimulus [GO:0071364],
negative regulation of protein serine/threonine kinase activity [GO:0071901],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of synapse maturation [GO:0090129],
positive regulation of dendrite development [GO:1900006],
regulation of p38MAPK cascade [GO:1900744],
negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747],
positive regulation of proteasomal protein catabolic process [GO:1901800],
negative regulation of cellular protein catabolic process [GO:1903363],
positive regulation of neuron migration [GO:2001224],
positive regulation of apoptotic signaling pathway [GO:2001235],
MAPK cascade [GO:0000165],
cellular response to unfolded protein [GO:0034620],
positive regulation of GTPase activity [GO:0043547],
endothelial cell apoptotic process [GO:0072577],
positive regulation of IRE1-mediated unfolded protein response [GO:1903896],

Molecular Function:
GTPase activator activity [GO:0005096],
death receptor binding [GO:0005123],
protein binding [GO:0005515],
SH3 domain binding [GO:0017124],
kinase binding [GO:0019900],
protein kinase binding [GO:0019901],
mitogen-activated protein kinase kinase binding [GO:0031434],
mitogen-activated protein kinase kinase kinase binding [GO:0031435],
phosphatidylinositol-3-phosphate binding [GO:0032266],
signaling adaptor activity [GO:0035591],
Toll-like receptor 4 binding [GO:0035662],
phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
vascular endothelial growth factor receptor 2 binding [GO:0043184],
phosphatidylinositol 3-kinase binding [GO:0043548],
macromolecular complex binding [GO:0044877],
protein N-terminus binding [GO:0047485],
protein phosphatase 2A binding [GO:0051721],
phosphatidylinositol-4-phosphate binding [GO:0070273],
14-3-3 protein binding [GO:0071889],
cadherin binding [GO:0045296],

Cellular Component:
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
membrane [GO:0016020],
endocytic vesicle [GO:0030139],
axon [GO:0030424],
neuronal cell body membrane [GO:0032809],
cell projection [GO:0042995],
neuronal cell body [GO:0043025],
cerebellar mossy fiber [GO:0044300],
climbing fiber [GO:0044301],
parallel fiber [GO:1990032],
AIP1-IRE1 complex [GO:1990597],
cytosol [GO:0005829],
dendrite [GO:0030425],