D-2-hydroxyglutarate dehydrogenase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
response to manganese ion [GO:0010042],
response to zinc ion [GO:0010043],
response to cobalt ion [GO:0032025],
response to magnesium ion [GO:0032026],
cellular protein metabolic process [GO:0044267],
response to calcium ion [GO:0051592],
oxidation-reduction process [GO:0055114],
2-oxoglutarate metabolic process [GO:0006103],

Molecular Function:
catalytic activity [GO:0003824],
oxidoreductase activity [GO:0016491],
flavin adenine dinucleotide binding [GO:0050660],
(R)-2-hydroxyglutarate dehydrogenase activity [GO:0051990],
FAD binding [GO:0071949],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],