AGTR1

angiotensin II receptor type 1

Link to human ortholog


Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16097371 EPC Human NO
17706954 VSMC Rat NO
24548645 Aorta Rat NO
31158660 Primary endothelial cells derived from artery Pig NO
31581517 Primary cells derived form heart Pig NO
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
regulation of cell growth [GO:0001558],
kidney development [GO:0001822],
renin-angiotensin regulation of aldosterone production [GO:0002018],
regulation of blood vessel size by renin-angiotensin [GO:0002034],
regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081],
inflammatory response [GO:0006954],
G-protein coupled receptor signaling pathway [GO:0007186],
phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
Rho protein signal transduction [GO:0007266],
positive regulation of macrophage derived foam cell differentiation [GO:0010744],
positive regulation of cholesterol esterification [GO:0010873],
regulation of vasoconstriction [GO:0019229],
calcium-mediated signaling [GO:0019722],
positive regulation of cellular protein metabolic process [GO:0032270],
positive regulation of phospholipase A2 activity [GO:0032430],
positive regulation of NAD(P)H oxidase activity [GO:0033864],
low-density lipoprotein particle remodeling [GO:0034374],
regulation of renal sodium excretion [GO:0035813],
angiotensin-activated signaling pathway [GO:0038166],
regulation of cell proliferation [GO:0042127],
regulation of inflammatory response [GO:0050727],
positive regulation of inflammatory response [GO:0050729],
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482],
cell chemotaxis [GO:0060326],
phospholipase C-activating angiotensin-activated signaling pathway [GO:0086097],
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589],
positive regulation of reactive oxygen species metabolic process [GO:2000379],

Molecular Function:
angiotensin type I receptor activity [GO:0001596],
G-protein coupled receptor activity [GO:0004930],
angiotensin type II receptor activity [GO:0004945],
protein binding [GO:0005515],
bradykinin receptor binding [GO:0031711],
protein heterodimerization activity [GO:0046982],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
integral component of membrane [GO:0016021],