AGTR1
angiotensin II receptor type 1
Link to human orthologSearch for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 16097371 | EPC | Human | NO | |
| 17706954 | VSMC | Rat | NO | |
| 24548645 | Aorta | Rat | NO | |
| 31158660 | Primary endothelial cells derived from artery | Pig | NO | |
| 31581517 | Primary cells derived form heart | Pig | NO | |
| 31945054 | IMR-90 | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29548335 | Li Fraumeni | Human | YES | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
GO terms:
Biological Process:
regulation of cell growth [GO:0001558],
kidney development [GO:0001822],
renin-angiotensin regulation of aldosterone production [GO:0002018],
regulation of blood vessel size by renin-angiotensin [GO:0002034],
regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081],
inflammatory response [GO:0006954],
G-protein coupled receptor signaling pathway [GO:0007186],
phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
Rho protein signal transduction [GO:0007266],
positive regulation of macrophage derived foam cell differentiation [GO:0010744],
positive regulation of cholesterol esterification [GO:0010873],
regulation of vasoconstriction [GO:0019229],
calcium-mediated signaling [GO:0019722],
positive regulation of cellular protein metabolic process [GO:0032270],
positive regulation of phospholipase A2 activity [GO:0032430],
positive regulation of NAD(P)H oxidase activity [GO:0033864],
low-density lipoprotein particle remodeling [GO:0034374],
regulation of renal sodium excretion [GO:0035813],
angiotensin-activated signaling pathway [GO:0038166],
regulation of cell proliferation [GO:0042127],
regulation of inflammatory response [GO:0050727],
positive regulation of inflammatory response [GO:0050729],
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482],
cell chemotaxis [GO:0060326],
phospholipase C-activating angiotensin-activated signaling pathway [GO:0086097],
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
Molecular Function:
angiotensin type I receptor activity [GO:0001596],
G-protein coupled receptor activity [GO:0004930],
angiotensin type II receptor activity [GO:0004945],
protein binding [GO:0005515],
bradykinin receptor binding [GO:0031711],
protein heterodimerization activity [GO:0046982],
Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
integral component of membrane [GO:0016021],