AGT

angiotensinogen

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21352808 VSMC Human NO
22072715 VSMCs Aorta Human, mouse NO
29548335 Li Fraumeni Human YES
30790400 Primary endothelial cells derived from lung Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
regulation of cell growth [GO:0001558],
positive regulation of cytokine production [GO:0001819],
kidney development [GO:0001822],
blood vessel remodeling [GO:0001974],
regulation of blood volume by renin-angiotensin [GO:0002016],
renin-angiotensin regulation of aldosterone production [GO:0002018],
regulation of renal output by angiotensin [GO:0002019],
regulation of heart rate [GO:0002027],
regulation of blood vessel size by renin-angiotensin [GO:0002034],
renal system process [GO:0003014],
angiotensin-mediated drinking behavior [GO:0003051],
positive regulation of extracellular matrix constituent secretion [GO:0003331],
protein import into nucleus [GO:0006606],
cellular sodium ion homeostasis [GO:0006883],
cell surface receptor signaling pathway [GO:0007166],
G-protein coupled receptor signaling pathway [GO:0007186],
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [GO:0007199],
phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200],
activation of phospholipase C activity [GO:0007202],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
nitric oxide mediated signal transduction [GO:0007263],
cell-cell signaling [GO:0007267],
female pregnancy [GO:0007565],
aging [GO:0007568],
regulation of blood pressure [GO:0008217],
associative learning [GO:0008306],
positive regulation of activation of Janus kinase activity [GO:0010536],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
positive regulation of cardiac muscle cell apoptotic process [GO:0010666],
positive regulation of macrophage derived foam cell differentiation [GO:0010744],
positive regulation of cholesterol esterification [GO:0010873],
negative regulation of endopeptidase activity [GO:0010951],
positive regulation of neuron projection development [GO:0010976],
regulation of norepinephrine secretion [GO:0014061],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
artery smooth muscle contraction [GO:0014824],
response to muscle activity involved in regulation of muscle adaptation [GO:0014873],
negative regulation of angiogenesis [GO:0016525],
regulation of lipid metabolic process [GO:0019216],
regulation of vasoconstriction [GO:0019229],
negative regulation of cell growth [GO:0030308],
positive regulation of cellular protein metabolic process [GO:0032270],
response to estradiol [GO:0032355],
positive regulation of superoxide anion generation [GO:0032930],
positive regulation of NAD(P)H oxidase activity [GO:0033864],
negative regulation of tissue remodeling [GO:0034104],
low-density lipoprotein particle remodeling [GO:0034374],
operant conditioning [GO:0035106],
regulation of renal sodium excretion [GO:0035813],
positive regulation of renal sodium excretion [GO:0035815],
regulation of cell proliferation [GO:0042127],
vasodilation [GO:0042311],
negative regulation of MAP kinase activity [GO:0043407],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742],
positive regulation of blood pressure [GO:0045777],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of insulin receptor signaling pathway [GO:0046628],
fibroblast proliferation [GO:0048144],
positive regulation of fibroblast proliferation [GO:0048146],
regulation of long-term neuronal synaptic plasticity [GO:0048169],
smooth muscle cell proliferation [GO:0048659],
cytokine secretion [GO:0050663],
positive regulation of inflammatory response [GO:0050729],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387],
stress-activated MAPK cascade [GO:0051403],
regulation of calcium ion transport [GO:0051924],
regulation of transmission of nerve impulse [GO:0051969],
cell growth involved in cardiac muscle cell development [GO:0061049],
positive regulation of protein tyrosine kinase activity [GO:0061098],
ERK1 and ERK2 cascade [GO:0070371],
uterine smooth muscle contraction [GO:0070471],
cellular response to mechanical stimulus [GO:0071260],
positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190],
regulation of extracellular matrix assembly [GO:1901201],
positive regulation of gap junction assembly [GO:1903598],
regulation of cardiac conduction [GO:1903779],
cellular response to angiotensin [GO:1904385],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
positive regulation of vascular associated smooth muscle cell migration [GO:1904754],
positive regulation of L-lysine import into cell [GO:1905010],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238],
ovarian follicle rupture [GO:0001543],
blood vessel development [GO:0001568],
branching involved in ureteric bud morphogenesis [GO:0001658],
regulation of systemic arterial blood pressure by circulatory renin-angiotensin [GO:0001991],
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001998],
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [GO:0001999],
brain renin-angiotensin system [GO:0002035],
cell-matrix adhesion [GO:0007160],
activation of NF-kappaB-inducing kinase activity [GO:0007250],
excretion [GO:0007588],
establishment of blood-nerve barrier [GO:0008065],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
response to cold [GO:0009409],
response to salt stress [GO:0009651],
regulation of gene expression [GO:0010468],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
extracellular matrix organization [GO:0030198],
peristalsis [GO:0030432],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
angiotensin-activated signaling pathway [GO:0038166],
positive regulation of multicellular organism growth [GO:0040018],
vasoconstriction [GO:0042310],
hormone metabolic process [GO:0042445],
drinking behavior [GO:0042756],
regulation of apoptotic process [GO:0042981],
positive regulation of catalytic activity [GO:0043085],
positive regulation of MAPK cascade [GO:0043410],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of fatty acid biosynthetic process [GO:0045723],
positive regulation of organ growth [GO:0046622],
astrocyte activation [GO:0048143],
positive regulation of cytokine secretion [GO:0050715],
regulation of inflammatory response [GO:0050727],
smooth muscle cell differentiation [GO:0051145],
positive regulation of protein kinase C activity [GO:1900020],
positive regulation of membrane hyperpolarization [GO:1902632],

Molecular Function:
serine-type endopeptidase inhibitor activity [GO:0004867],
hormone activity [GO:0005179],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
type 1 angiotensin receptor binding [GO:0031702],
type 2 angiotensin receptor binding [GO:0031703],
sodium channel regulator activity [GO:0017080],
receptor agonist activity [GO:0048018],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytosol [GO:0005829],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],
cytoplasm [GO:0005737],