CYBB

cytochrome b-245 beta chain

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27181082 Primary endothelial progenitor cells derived from blood Human NO
28499911 CMEC Mouse NO
30401703 Primary AML blasts and BMSCs derived from bone marrow Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33428925 MEF Mouse No

GO terms:

Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479],
superoxide metabolic process [GO:0006801],
defense response [GO:0006952],
inflammatory response [GO:0006954],
electron transport chain [GO:0022900],
ion transmembrane transport [GO:0034220],
cellular response to oxidative stress [GO:0034599],
regulation of ion transmembrane transport [GO:0034765],
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535],
superoxide anion generation [GO:0042554],
neutrophil degranulation [GO:0043312],
innate immune response [GO:0045087],
cell redox homeostasis [GO:0045454],
respiratory burst [GO:0045730],
positive regulation of angiogenesis [GO:0045766],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
hydrogen peroxide biosynthetic process [GO:0050665],
oxidation-reduction process [GO:0055114],
cellular response to cadmium ion [GO:0071276],
cellular response to ethanol [GO:0071361],
hypoxia-inducible factor-1alpha signaling pathway [GO:0097411],
response to aldosterone [GO:1904044],
cellular response to L-glutamine [GO:1904845],
response to angiotensin [GO:1990776],
ion transport [GO:0006811],
response to drug [GO:0042493],

Molecular Function:
voltage-gated ion channel activity [GO:0005244],
protein binding [GO:0005515],
electron carrier activity [GO:0009055],
superoxide-generating NADPH oxidase activity [GO:0016175],
heme binding [GO:0020037],
metal ion binding [GO:0046872],
protein heterodimerization activity [GO:0046982],
flavin adenine dinucleotide binding [GO:0050660],
oxidoreductase activity [GO:0016491],

Cellular Component:
nuclear envelope [GO:0005635],
endoplasmic reticulum membrane [GO:0005789],
rough endoplasmic reticulum [GO:0005791],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
dendrite [GO:0030425],
phagocytic vesicle membrane [GO:0030670],
specific granule membrane [GO:0035579],
NADPH oxidase complex [GO:0043020],
neuronal cell body [GO:0043025],
tertiary granule membrane [GO:0070821],
perinuclear endoplasmic reticulum [GO:0097038],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
phagocytic vesicle [GO:0045335],