AGO4

argonaute RISC component 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
mRNA catabolic process [GO:0006402],
regulation of translation [GO:0006417],
synaptonemal complex assembly [GO:0007130],
male meiosis [GO:0007140],
male gonad development [GO:0008584],
RNA secondary structure unwinding [GO:0010501],
miRNA metabolic process [GO:0010586],
regulation of cell morphogenesis [GO:0022604],
gene silencing by RNA [GO:0031047],
pre-miRNA processing [GO:0031054],
production of miRNAs involved in gene silencing by miRNA [GO:0035196],
miRNA mediated inhibition of translation [GO:0035278],
miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280],
negative regulation of apoptotic process [GO:0043066],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
posttranscriptional gene silencing by RNA [GO:0035194],
mRNA cleavage involved in gene silencing by miRNA [GO:0035279],
regulation of megakaryocyte differentiation [GO:0045652],
mRNA cleavage involved in gene silencing by siRNA [GO:0090625],

Molecular Function:
nucleic acid binding [GO:0003676],
RNA binding [GO:0003723],
double-stranded RNA binding [GO:0003725],
single-stranded RNA binding [GO:0003727],
miRNA binding [GO:0035198],
protein binding [GO:0005515],

Cellular Component:
cytoplasmic mRNA processing body [GO:0000932],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
RISC complex [GO:0016442],
RISC-loading complex [GO:0070578],
cytosol [GO:0005829],
membrane [GO:0016020],