argonaute RISC catalytic component 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
mRNA catabolic process [GO:0006402],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
RNA secondary structure unwinding [GO:0010501],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
pre-miRNA processing [GO:0031054],
posttranscriptional gene silencing by RNA [GO:0035194],
production of miRNAs involved in gene silencing by miRNA [GO:0035196],
miRNA mediated inhibition of translation [GO:0035278],
mRNA cleavage involved in gene silencing by miRNA [GO:0035279],
miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280],
regulation of megakaryocyte differentiation [GO:0045652],
regulation of stem cell proliferation [GO:0072091],
RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502],
mRNA cleavage involved in gene silencing by siRNA [GO:0090625],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
regulation of translation [GO:0006417],
gene silencing by RNA [GO:0031047],

Molecular Function:
RNA binding [GO:0003723],
double-stranded RNA binding [GO:0003725],
single-stranded RNA binding [GO:0003727],
endoribonuclease activity [GO:0004521],
protein binding [GO:0005515],
miRNA binding [GO:0035198],
metal ion binding [GO:0046872],
endoribonuclease activity, cleaving miRNA-paired mRNA [GO:0090624],
nucleic acid binding [GO:0003676],
nuclease activity [GO:0004518],
endonuclease activity [GO:0004519],
hydrolase activity [GO:0016787],

Cellular Component:
condensed nuclear chromosome [GO:0000794],
cytoplasmic mRNA processing body [GO:0000932],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
membrane [GO:0016020],
RISC complex [GO:0016442],
cytoplasmic ribonucleoprotein granule [GO:0036464],
RISC-loading complex [GO:0070578],