CXCL10

C-X-C motif chemokine ligand 10

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31155496 MIN6 Pancreas Mouse,Human NO
31183403 IMR-90 Human YES
31186408 OV-90,OV-1369, OV-1946 Human YES
31219154 MCF10A Human YES
31431479 B16-F1 Human NO
31578521 Huh-7, Hep 3B Human NO
31616512 AML12 Mouse NO
32023351 Primary bone cells derived from bone marrow Mouse NO
32466233 TIG-3 Human NO
33470505 brain Mouse No

GO terms:

Biological Process:
chemotaxis [GO:0006935],
inflammatory response [GO:0006954],
immune response [GO:0006955],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
cell-cell signaling [GO:0007267],
muscle organ development [GO:0007517],
blood circulation [GO:0008015],
positive regulation of cell proliferation [GO:0008284],
response to cold [GO:0009409],
response to gamma radiation [GO:0010332],
T cell chemotaxis [GO:0010818],
regulation of T cell chemotaxis [GO:0010819],
response to auditory stimulus [GO:0010996],
negative regulation of angiogenesis [GO:0016525],
cytokine-mediated signaling pathway [GO:0019221],
neutrophil chemotaxis [GO:0030593],
leukocyte chemotaxis [GO:0030595],
response to vitamin D [GO:0033280],
cellular response to heat [GO:0034605],
endothelial cell activation [GO:0042118],
regulation of cell proliferation [GO:0042127],
regulation of apoptotic process [GO:0042981],
negative regulation of myoblast differentiation [GO:0045662],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive chemotaxis [GO:0050918],
positive regulation of release of sequestered calcium ion into cytosol [GO:0051281],
defense response to virus [GO:0051607],
chemokine-mediated signaling pathway [GO:0070098],
cellular response to lipopolysaccharide [GO:0071222],
positive regulation of monocyte chemotaxis [GO:0090026],
regulation of endothelial tube morphogenesis [GO:1901509],
negative regulation of myoblast fusion [GO:1901740],
positive regulation of T cell migration [GO:2000406],
regulation of cAMP-dependent protein kinase activity [GO:2000479],
positive regulation of leukocyte chemotaxis [GO:0002690],
defense response [GO:0006952],
response to bacterium [GO:0009617],
positive regulation of cell migration [GO:0030335],
killing of cells of other organism [GO:0031640],

Molecular Function:
receptor binding [GO:0005102],
protein binding [GO:0005515],
chemokine activity [GO:0008009],
heparin binding [GO:0008201],
cAMP-dependent protein kinase regulator activity [GO:0008603],
chemoattractant activity [GO:0042056],
CXCR chemokine receptor binding [GO:0045236],
CXCR3 chemokine receptor binding [GO:0048248],
cytokine activity [GO:0005125],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
external side of plasma membrane [GO:0009897],