AGO1

argonaute RISC component 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
nuclear-transcribed mRNA catabolic process [GO:0000956],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
RNA secondary structure unwinding [GO:0010501],
miRNA metabolic process [GO:0010586],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
negative regulation of angiogenesis [GO:0016525],
pre-miRNA processing [GO:0031054],
posttranscriptional gene silencing by RNA [GO:0035194],
production of miRNAs involved in gene silencing by miRNA [GO:0035196],
miRNA mediated inhibition of translation [GO:0035278],
mRNA cleavage involved in gene silencing by miRNA [GO:0035279],
miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280],
regulation of megakaryocyte differentiation [GO:0045652],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of gene silencing by miRNA [GO:0060964],
RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502],
mRNA cleavage involved in gene silencing by siRNA [GO:0090625],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
regulation of translation [GO:0006417],
gene silencing by RNA [GO:0031047],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II core binding [GO:0000993],
core promoter sequence-specific DNA binding [GO:0001046],
RNA binding [GO:0003723],
double-stranded RNA binding [GO:0003725],
single-stranded RNA binding [GO:0003727],
endoribonuclease activity [GO:0004521],
protein binding [GO:0005515],
miRNA binding [GO:0035198],
transcription regulatory region sequence-specific DNA binding [GO:0000976],
nucleic acid binding [GO:0003676],

Cellular Component:
cytoplasmic mRNA processing body [GO:0000932],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
polysome [GO:0005844],
RISC complex [GO:0016442],
RISC-loading complex [GO:0070578],
ribonucleoprotein complex [GO:1990904],