ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
signal transduction [GO:0007165],
cellular response to reactive oxygen species [GO:0034614],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
positive regulation of GTPase activity [GO:0043547],
protein import into nucleus [GO:0006606],
PML body organization [GO:0030578],
cellular response to UV [GO:0034644],

Molecular Function:
GTPase activity [GO:0003924],
GTPase activator activity [GO:0005096],
GTP binding [GO:0005525],
polyubiquitin binding [GO:0031593],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
membrane [GO:0016020],
cell periphery [GO:0071944],
PML body [GO:0016605],