CTSB

cathepsin B

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31155496 Primary β cells derived from pancreas Mouse YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
toll-like receptor signaling pathway [GO:0002224],
proteolysis [GO:0006508],
thyroid hormone generation [GO:0006590],
collagen catabolic process [GO:0030574],
epithelial cell differentiation [GO:0030855],
regulation of apoptotic process [GO:0042981],
neutrophil degranulation [GO:0043312],
decidualization [GO:0046697],
viral entry into host cell [GO:0046718],
regulation of catalytic activity [GO:0050790],
proteolysis involved in cellular protein catabolic process [GO:0051603],
cellular response to thyroid hormone stimulus [GO:0097067],
negative regulation of cell death [GO:0060548],

Molecular Function:
cysteine-type endopeptidase activity [GO:0004197],
protein binding [GO:0005515],
collagen binding [GO:0005518],
peptidase activity [GO:0008233],
cysteine-type peptidase activity [GO:0008234],
proteoglycan binding [GO:0043394],
endopeptidase activity [GO:0004175],
hydrolase activity [GO:0016787],
kininogen binding [GO:0030984],
peptide binding [GO:0042277],
protein self-association [GO:0043621],
macromolecular complex binding [GO:0044877],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
intracellular [GO:0005622],
nucleolus [GO:0005730],
lysosome [GO:0005764],
external side of plasma membrane [GO:0009897],
apical plasma membrane [GO:0016324],
endolysosome lumen [GO:0036021],
melanosome [GO:0042470],
intracellular membrane-bounded organelle [GO:0043231],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
ficolin-1-rich granule lumen [GO:1904813],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
plasma membrane [GO:0005886],
caveola [GO:0005901],
cell surface [GO:0009986],
membrane [GO:0016020],
sarcolemma [GO:0042383],