CTNNA1

catenin alpha 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
ovarian follicle development [GO:0001541],
cell adhesion [GO:0007155],
establishment or maintenance of cell polarity [GO:0007163],
negative regulation of neuroblast proliferation [GO:0007406],
aging [GO:0007568],
male gonad development [GO:0008584],
gap junction assembly [GO:0016264],
axon regeneration [GO:0031103],
adherens junction organization [GO:0034332],
cellular protein localization [GO:0034613],
odontogenesis of dentin-containing tooth [GO:0042475],
apical junction assembly [GO:0043297],
response to estrogen [GO:0043627],
positive regulation of smoothened signaling pathway [GO:0045880],
positive regulation of muscle cell differentiation [GO:0051149],
cellular response to indole-3-methanol [GO:0071681],
epithelial cell-cell adhesion [GO:0090136],
negative regulation of cell motility [GO:2000146],
negative regulation of integrin-mediated signaling pathway [GO:2001045],
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240],
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241],
regulation of cell proliferation [GO:0042127],
negative regulation of apoptotic process [GO:0043066],

Molecular Function:
RNA binding [GO:0003723],
structural molecule activity [GO:0005198],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
vinculin binding [GO:0017166],
identical protein binding [GO:0042802],
gamma-catenin binding [GO:0045295],
cadherin binding [GO:0045296],
actin filament binding [GO:0051015],
macromolecular complex binding [GO:0044877],

Cellular Component:
acrosomal vesicle [GO:0001669],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
zonula adherens [GO:0005915],
focal adhesion [GO:0005925],
intercalated disc [GO:0014704],
actin cytoskeleton [GO:0015629],
catenin complex [GO:0016342],
flotillin complex [GO:0016600],
lamellipodium [GO:0030027],
cell junction [GO:0030054],
intracellular membrane-bounded organelle [GO:0043231],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
adherens junction [GO:0005912],
membrane [GO:0016020],