AFG3 like matrix AAA peptidase subunit 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
mitochondrial calcium ion transport [GO:0006851],
axonogenesis [GO:0007409],
neuromuscular junction development [GO:0007528],
mitochondrial fusion [GO:0008053],
protein processing [GO:0016485],
protein autoprocessing [GO:0016540],
nerve development [GO:0021675],
membrane protein proteolysis [GO:0033619],
mitochondrial protein processing [GO:0034982],
calcium ion transmembrane import into mitochondrion [GO:0036444],
regulation of multicellular organism growth [GO:0040014],
cristae formation [GO:0042407],
myelination [GO:0042552],
muscle fiber development [GO:0048747],
mitochondrial calcium ion homeostasis [GO:0051560],
righting reflex [GO:0060013],
macromolecular complex assembly [GO:0065003],
mitochondrion organization [GO:0007005],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
ATP binding [GO:0005524],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
unfolded protein binding [GO:0051082],
nucleotide binding [GO:0000166],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial inner membrane [GO:0005743],
m-AAA complex [GO:0005745],
membrane [GO:0016020],
integral component of membrane [GO:0016021],