CSF1R

colony stimulating factor 1 receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
positive regulation of protein phosphorylation [GO:0001934],
hematopoietic progenitor cell differentiation [GO:0002244],
response to ischemia [GO:0002931],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
multicellular organism development [GO:0007275],
axon guidance [GO:0007411],
cell proliferation [GO:0008283],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
regulation of cell shape [GO:0008360],
positive regulation of macrophage chemotaxis [GO:0010759],
peptidyl-tyrosine phosphorylation [GO:0018108],
cytokine-mediated signaling pathway [GO:0019221],
olfactory bulb development [GO:0021772],
forebrain neuron differentiation [GO:0021879],
hemopoiesis [GO:0030097],
monocyte differentiation [GO:0030224],
macrophage differentiation [GO:0030225],
osteoclast differentiation [GO:0030316],
positive regulation of cell migration [GO:0030335],
ruffle organization [GO:0031529],
positive regulation of kinase activity [GO:0033674],
cellular response to macrophage colony-stimulating factor stimulus [GO:0036006],
macrophage colony-stimulating factor signaling pathway [GO:0038145],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
negative regulation of apoptotic process [GO:0043066],
positive regulation by host of viral process [GO:0044794],
innate immune response [GO:0045087],
regulation of bone resorption [GO:0045124],
cell-cell junction maintenance [GO:0045217],
phosphatidylinositol metabolic process [GO:0046488],
protein autophosphorylation [GO:0046777],
phosphatidylinositol-mediated signaling [GO:0048015],
mammary gland duct morphogenesis [GO:0060603],
positive regulation of protein tyrosine kinase activity [GO:0061098],
microglial cell proliferation [GO:0061518],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to cytokine stimulus [GO:0071345],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
positive regulation of chemokine secretion [GO:0090197],
positive regulation of cell motility [GO:2000147],
regulation of actin cytoskeleton reorganization [GO:2000249],
immune system process [GO:0002376],
protein phosphorylation [GO:0006468],
phosphorylation [GO:0016310],
positive regulation of osteoclast differentiation [GO:0045672],

Molecular Function:
protein tyrosine kinase activity [GO:0004713],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
macrophage colony-stimulating factor receptor activity [GO:0005011],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein phosphatase binding [GO:0019903],
cytokine binding [GO:0019955],
protein homodimerization activity [GO:0042803],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleoplasm [GO:0005654],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
intracellular membrane-bounded organelle [GO:0043231],
receptor complex [GO:0043235],
CSF1-CSF1R complex [GO:1990682],
membrane [GO:0016020],
integral component of membrane [GO:0016021],