afadin, adherens junction formation factor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29159771 MDA-MB-231 Human NO

GO terms:

Biological Process:
cell adhesion [GO:0007155],
signal transduction [GO:0007165],
cell-cell signaling [GO:0007267],
positive regulation of gene expression [GO:0010628],
positive regulation of cell-cell adhesion [GO:0022409],
negative regulation of cell migration [GO:0030336],
regulation of protein localization [GO:0032880],
adherens junction organization [GO:0034332],
positive regulation of GTPase activity [GO:0043547],
cell-cell adhesion mediated by cadherin [GO:0044331],
pore complex assembly [GO:0046931],
bicellular tight junction assembly [GO:0070830],
establishment of endothelial intestinal barrier [GO:0090557],
positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049],
telencephalon development [GO:0021537],
cerebral cortex development [GO:0021987],
adherens junction maintenance [GO:0034334],
brain morphogenesis [GO:0048854],
homeostasis of number of cells [GO:0048872],
positive regulation of dendrite morphogenesis [GO:0050775],
radial glial cell differentiation [GO:0060019],
neuroepithelial cell differentiation [GO:0060563],
positive regulation of dendritic spine morphogenesis [GO:0061003],
regulation of oligodendrocyte progenitor proliferation [GO:0070445],
protein localization to cell junction [GO:1902414],
positive regulation of dendrite extension [GO:1903861],

Molecular Function:
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
Ras GTPase binding [GO:0017016],
cadherin binding [GO:0045296],
cell adhesion molecule binding [GO:0050839],
actin filament binding [GO:0051015],
LIM domain binding [GO:0030274],

Cellular Component:
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
adherens junction [GO:0005912],
nuclear speck [GO:0016607],
cell junction [GO:0030054],
cell-cell contact zone [GO:0044291],
pore complex [GO:0046930],
occluding junction [GO:0070160],
cytoplasm [GO:0005737],
axon [GO:0030424],
somatodendritic compartment [GO:0036477],
apical junction complex [GO:0043296],
apical part of cell [GO:0045177],
excitatory synapse [GO:0060076],