CRYAB

crystallin alpha B

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30977188 MSC Human YES
31811565 Primary neuronal cells derived from brain Brain Human, mouse, rat YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
lens development in camera-type eye [GO:0002088],
protein folding [GO:0006457],
muscle contraction [GO:0006936],
tubulin complex assembly [GO:0007021],
muscle organ development [GO:0007517],
multicellular organism aging [GO:0010259],
regulation of cell death [GO:0010941],
negative regulation of cell growth [GO:0030308],
microtubule polymerization or depolymerization [GO:0031109],
negative regulation of protein complex assembly [GO:0031333],
response to estradiol [GO:0032355],
negative regulation of intracellular transport [GO:0032387],
response to hydrogen peroxide [GO:0042542],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
negative regulation of transcription, DNA-templated [GO:0045892],
protein stabilization [GO:0050821],
stress-activated MAPK cascade [GO:0051403],
apoptotic process involved in morphogenesis [GO:0060561],
cellular response to gamma radiation [GO:0071480],
regulation of cellular response to heat [GO:1900034],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
negative regulation of gene expression [GO:0010629],
camera-type eye development [GO:0043010],

Molecular Function:
beta-amyloid binding [GO:0001540],
structural molecule activity [GO:0005198],
structural constituent of eye lens [GO:0005212],
protein binding [GO:0005515],
microtubule binding [GO:0008017],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],
unfolded protein binding [GO:0051082],
cytoskeletal protein binding [GO:0008092],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
cell surface [GO:0009986],
postsynaptic density [GO:0014069],
microtubule cytoskeleton [GO:0015630],
Z disc [GO:0030018],
axon [GO:0030424],
M band [GO:0031430],
actin filament bundle [GO:0032432],
macromolecular complex [GO:0032991],
dendritic spine [GO:0043197],
perikaryon [GO:0043204],
extracellular exosome [GO:0070062],
synaptic membrane [GO:0097060],
cardiac myofibril [GO:0097512],
plasma membrane [GO:0005886],
I band [GO:0031674],
myelin sheath [GO:0043209],
contractile fiber [GO:0043292],
synapse [GO:0045202],