AEN
apoptosis enhancing nuclease
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
GO terms:
Biological Process:
response to ionizing radiation [GO:0010212],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
apoptotic process [GO:0006915],
cellular response to DNA damage stimulus [GO:0006974],
Molecular Function:
nucleic acid binding [GO:0003676],
exonuclease activity [GO:0004527],
protein binding [GO:0005515],
nuclease activity [GO:0004518],
hydrolase activity [GO:0016787],
Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
nuclear membrane [GO:0031965],