AEN

apoptosis enhancing nuclease

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
response to ionizing radiation [GO:0010212],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
apoptotic process [GO:0006915],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
nucleic acid binding [GO:0003676],
exonuclease activity [GO:0004527],
protein binding [GO:0005515],
nuclease activity [GO:0004518],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
nuclear membrane [GO:0031965],