CREB3

cAMP responsive element binding protein 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA77 Skin, Lung Human YES

GO terms:

Biological Process:
chemotaxis [GO:0006935],
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990],
viral process [GO:0016032],
endoplasmic reticulum unfolded protein response [GO:0030968],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of monocyte chemotaxis [GO:0090026],
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236],
regulation of cell growth [GO:0001558],
positive regulation of defense response to virus by host [GO:0002230],
transcription, DNA-templated [GO:0006351],
regulation of transcription, DNA-templated [GO:0006355],
response to unfolded protein [GO:0006986],
establishment of viral latency [GO:0019043],
release from viral latency [GO:0019046],
positive regulation of cell migration [GO:0030335],
regulation of cell proliferation [GO:0042127],
regulation of apoptotic process [GO:0042981],
cytoplasmic sequestering of transcription factor [GO:0042994],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of calcium ion transport [GO:0051928],
positive regulation of deacetylase activity [GO:0090045],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
protein binding [GO:0005515],
cAMP response element binding [GO:0035497],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
cAMP response element binding protein binding [GO:0008140],
CCR1 chemokine receptor binding [GO:0031726],
protein homodimerization activity [GO:0042803],
sequence-specific DNA binding [GO:0043565],

Cellular Component:
Golgi membrane [GO:0000139],
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
integral component of membrane [GO:0016021],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
membrane [GO:0016020],
nuclear body [GO:0016604],
integral component of endoplasmic reticulum membrane [GO:0030176],
neuronal cell body [GO:0043025],