carboxypeptidase E

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2, Li-Fraumeni Human YES
30977188 MSC Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
cardiac left ventricle morphogenesis [GO:0003214],
cellular protein modification process [GO:0006464],
peptide metabolic process [GO:0006518],
neuropeptide signaling pathway [GO:0007218],
Wnt signaling pathway [GO:0016055],
protein processing [GO:0016485],
insulin processing [GO:0030070],
peptide hormone secretion [GO:0030072],
protein localization to secretory granule [GO:0033366],
protein localization to membrane [GO:0072657],
proteolysis [GO:0006508],
enkephalin processing [GO:0034230],
peptide catabolic process [GO:0043171],
negative regulation of branching morphogenesis of a nerve [GO:2000173],

Molecular Function:
carboxypeptidase activity [GO:0004180],
metallocarboxypeptidase activity [GO:0004181],
zinc ion binding [GO:0008270],
neurexin family protein binding [GO:0042043],
cell adhesion molecule binding [GO:0050839],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
protein domain specific binding [GO:0019904],
metal ion binding [GO:0046872],
cobalt ion binding [GO:0050897],

Cellular Component:
extracellular space [GO:0005615],
nucleus [GO:0005634],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
transport vesicle membrane [GO:0030658],
secretory granule membrane [GO:0030667],
extracellular exosome [GO:0070062],
extracellular region [GO:0005576],
membrane [GO:0016020],
secretory granule [GO:0030141],
dendrite [GO:0030425],
dense core granule [GO:0031045],
cytoplasmic vesicle [GO:0031410],
neuronal cell body [GO:0043025],
perikaryon [GO:0043204],
membrane raft [GO:0045121],
synaptic membrane [GO:0097060],