CPD

carboxypeptidase D

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
peptide metabolic process [GO:0006518],
protein processing [GO:0016485],

Molecular Function:
metallocarboxypeptidase activity [GO:0004181],
serine-type carboxypeptidase activity [GO:0004185],
zinc ion binding [GO:0008270],
carboxypeptidase activity [GO:0004180],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],
protein phosphatase 2A binding [GO:0051721],

Cellular Component:
extracellular space [GO:0005615],
plasma membrane [GO:0005886],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
extracellular exosome [GO:0070062],
nucleus [GO:0005634],
trans-Golgi network [GO:0005802],
intracellular membrane-bounded organelle [GO:0043231],
perinuclear region of cytoplasm [GO:0048471],