CPA4

carboxypeptidase A4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
histone acetylation [GO:0016573],

Molecular Function:
metallocarboxypeptidase activity [GO:0004181],
zinc ion binding [GO:0008270],
carboxypeptidase activity [GO:0004180],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
cellular_component [GO:0005575],
extracellular space [GO:0005615],
extracellular region [GO:0005576],