ADRA2C

adrenoceptor alpha 2C

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188],
female pregnancy [GO:0007565],
negative regulation of norepinephrine secretion [GO:0010700],
platelet activation [GO:0030168],
activation of protein kinase B activity [GO:0032148],
negative regulation of epinephrine secretion [GO:0032811],
receptor transactivation [GO:0035624],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of vasoconstriction [GO:0045907],
regulation of insulin secretion [GO:0050796],
regulation of sensory perception of pain [GO:0051930],
negative regulation of uterine smooth muscle contraction [GO:0070473],
adrenergic receptor signaling pathway [GO:0071875],
adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880],
regulation of smooth muscle contraction [GO:0006940],
signal transduction [GO:0007165],
regulation of vasoconstriction [GO:0019229],

Molecular Function:
G-protein coupled receptor activity [GO:0004930],
alpha2-adrenergic receptor activity [GO:0004938],
protein binding [GO:0005515],
alpha-2A adrenergic receptor binding [GO:0031694],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],
epinephrine binding [GO:0051379],
adrenergic receptor activity [GO:0004935],

Cellular Component:
cytoplasm [GO:0005737],
endosome [GO:0005768],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
neuronal cell body [GO:0043025],
axon terminus [GO:0043679],
glutamatergic synapse [GO:0098978],
integral component of postsynaptic density membrane [GO:0099061],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
axon [GO:0030424],
integral component of postsynaptic membrane [GO:0099055],