COPS5

COP9 signalosome subunit 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31222857 HEp-2 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
20974137 MEF, 293T, HEK, primary cells derived from kindey Mouse NO
23127558 MEF, NIH 3T3,293T, HEK Mouse NO
23316279 MEF, NIH3T3, HEK Kidney Human NO

GO terms:

Biological Process:
protein deneddylation [GO:0000338],
nucleotide-excision repair, DNA damage recognition [GO:0000715],
transcription-coupled nucleotide-excision repair [GO:0006283],
transcription from RNA polymerase II promoter [GO:0006366],
translation [GO:0006412],
translational initiation [GO:0006413],
protein deubiquitination [GO:0016579],
negative regulation of apoptotic process [GO:0043066],
post-translational protein modification [GO:0043687],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of JNK cascade [GO:0046328],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
regulation of cell cycle [GO:0051726],
regulation of IRE1-mediated unfolded protein response [GO:1903894],
exosomal secretion [GO:1990182],
regulation of transcription, DNA-templated [GO:0006355],

Molecular Function:
transcription coactivator activity [GO:0003713],
translation initiation factor activity [GO:0003743],
metalloendopeptidase activity [GO:0004222],
thiol-dependent ubiquitin-specific protease activity [GO:0004843],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
NEDD8-specific protease activity [GO:0019784],
enzyme binding [GO:0019899],
macrophage migration inhibitory factor binding [GO:0035718],
metal ion binding [GO:0046872],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],

Cellular Component:
chromatin [GO:0000785],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
eukaryotic translation initiation factor 3 complex [GO:0005852],
synaptic vesicle [GO:0008021],
COP9 signalosome [GO:0008180],
perinuclear region of cytoplasm [GO:0048471],
transcription factor complex [GO:0005667],
cell junction [GO:0030054],
cytoplasmic vesicle [GO:0031410],
synapse [GO:0045202],