ABCA2

ATP binding cassette subfamily A member 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
regulation of transcription from RNA polymerase II promoter [GO:0006357],
lipid metabolic process [GO:0006629],
lipid transport [GO:0006869],
locomotory behavior [GO:0007626],
regulation of cholesterol esterification [GO:0010872],
central nervous system myelin formation [GO:0032289],
regulation of intracellular cholesterol transport [GO:0032383],
negative regulation of intracellular cholesterol transport [GO:0032384],
positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805],
response to drug [GO:0042493],
cholesterol homeostasis [GO:0042632],
positive regulation of amyloid precursor protein biosynthetic process [GO:0042986],
regulation of cholesterol biosynthetic process [GO:0045540],
sphingosine biosynthetic process [GO:0046512],
response to steroid hormone [GO:0048545],
regulation of endopeptidase activity [GO:0052548],
transmembrane transport [GO:0055085],
regulation of protein glycosylation [GO:0060049],
response to cholesterol [GO:0070723],
negative regulation of phospholipid biosynthetic process [GO:0071072],
negative regulation of sphingolipid biosynthetic process [GO:0090155],
cellular sphingolipid homeostasis [GO:0090156],
negative regulation of cholesterol efflux [GO:0090370],
ceramide translocation [GO:0099040],
regulation of post-translational protein modification [GO:1901873],
positive regulation of beta-amyloid formation [GO:1902004],
positive regulation of amyloid precursor protein catabolic process [GO:1902993],
regulation of protein localization to cell periphery [GO:1904375],
regulation of protein localization to cell surface [GO:2000008],
cholesterol metabolic process [GO:0008203],

Molecular Function:
nucleotide binding [GO:0000166],
lipid transporter activity [GO:0005319],
ATP binding [GO:0005524],
ATPase activity [GO:0016887],
ATPase activity, coupled to transmembrane movement of substances [GO:0042626],
endopeptidase regulator activity [GO:0061135],
ceramide-translocating ATPase activity [GO:0099038],

Cellular Component:
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
endosome [GO:0005768],
microtubule organizing center [GO:0005815],
plasma membrane [GO:0005886],
endosome membrane [GO:0010008],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cytoplasmic vesicle [GO:0031410],
ATP-binding cassette (ABC) transporter complex [GO:0043190],
intracellular membrane-bounded organelle [GO:0043231],